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  • Title: Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
    Author: Bhowmick S, Bose R, Pal M, Pal SP.
    Journal: Indian J Exp Biol; 1990 Feb; 28(2):190-2. PubMed ID: 2115022.
    Abstract:
    N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.
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