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  • Title: Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes.
    Author: Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA.
    Journal: J Antimicrob Chemother; 1990 May; 25(5):751-8. PubMed ID: 2115510.
    Abstract:
    Purified membranes of Listeria monocytogenes ATCC 15313 contain at least five penicillin-binding proteins. In two dicloxacillin-resistant mutants, derived from a sensitive parent strain, a 16-fold increase in the MIC of dicloxacillin was observed. A less-significant increase was detected in the MICs of other beta-lactam drugs. In the mutants, PBP 3 lost its strong affinity for dicloxacillin, but remained fully susceptible to binding of 125I-penicillin X, as compared with the wild-type strain. PBP 2 could not be detected in one of the mutants. No decrease in affinity for the radioactive tracer or dicloxacillin was detected in any other PBP of the resistant mutants.
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