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  • Title: [Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats].
    Author: Zhao HY, Qin X, Cao Y, Yang Y, Zhao SF.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2009 Aug; 25(3):408-10. PubMed ID: 21155249.
    Abstract:
    AIM: To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats. METHODS: The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected. RESULTS: Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01). CONCLUSION: Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.
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