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  • Title: Assessment of varicella vaccine effectiveness in Germany: a time-series approach.
    Author: Höhle M, Siedler A, Bader HM, Ludwig M, Heininger U, Von Kries R.
    Journal: Epidemiol Infect; 2011 Nov; 139(11):1710-9. PubMed ID: 21156098.
    Abstract:
    A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.
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