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  • Title: Interaction of intravenous methylprednisolone with oral cyclosporin.
    Author: Ubhi CS, Woodhouse L, Giles GR.
    Journal: Nephrol Dial Transplant; 1990; 5(5):376-8. PubMed ID: 2115629.
    Abstract:
    The plasma cyclosporin values during 17 consecutive rejection episodes in 13 renal allograft recipients have been monitored by high-performance liquid chromatography and radioimmunoassay. In response to anti-rejection therapy with intravenous methylprednisolone, there was a significant increase of greater than 100 ng/ml on only three occasions. We suggest that elevated cyclosporin values during rejection episodes should not be dismissed as the result of steroid therapy and that the original diagnosis must be reviewed.
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