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  • Title: 6,7-seco-ent-kaurane diterpenoids from Isodon sculponeatus with cytotoxic activity.
    Author: Li X, Pu JX, Weng ZY, Zhao Y, Zhao Y, Xiao WL, Sun HD.
    Journal: Chem Biodivers; 2010 Dec; 7(12):2888-96. PubMed ID: 21162001.
    Abstract:
    Six new 6,7-seco-ent-kaurane diterpenoids, sculponeatins N-S (1-6, resp.), together with eleven known analogues, 7-17, were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1-6 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR experiments, as well as HR-ESI-MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC₅₀ values of 0.21 and 0.29 μM, respectively. The structure-activity relationships are discussed.
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