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  • Title: Hemostimulating effects of immobilized hyaluronidase and their mechanisms during cytostatic-induced myelosuppression.
    Author: Dygai AM, Artamonov AV, Bekarev AA, Vereschagin EI, Zhdanov VV, Zyuz'kov GN, Udut EV, Khrichkova TY, Simanina EV, Stavrova LA, Miroshnichenko LA, Chaikovskiy AV, Madonov PG.
    Journal: Bull Exp Biol Med; 2010 Oct; 149(5):594-7. PubMed ID: 21165395.
    Abstract:
    We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.
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