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  • Title: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells.
    Author: Hu M, Fan J, Li H, Song K, Wang S, Cheng G, Peng X.
    Journal: Org Biomol Chem; 2011 Feb 21; 9(4):980-3. PubMed ID: 21165468.
    Abstract:
    A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.
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