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  • Title: Application of mid-IR spectroscopy for the characterization of pharmaceutical systems.
    Author: Van Eerdenbrugh B, Taylor LS.
    Journal: Int J Pharm; 2011 Sep 30; 417(1-2):3-16. PubMed ID: 21167267.
    Abstract:
    In this article, the use of mid-IR in pharmaceutical settings is reviewed. An overview of mid-IR instrumentation and sampling techniques is provided. Subsequently, different pharmaceutical applications of the technique are described, including structure elucidation and identification, characterization of crystalline (polymorphs, hydrates, salts and co-crystals) and amorphous forms, as well as quantitative and remote sensing applications. Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR-AFM coupled techniques which have high spatial resolution.
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