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  • Title: Effect of prolonged intravenous infusion of gludopa in humans and a preliminary study of its oral bioavailability.
    Author: Freestone S, Ellis R, MacDonald TM, Lee MR.
    Journal: Am J Hypertens; 1990 Jun; 3(6 Pt 2):126S-129S. PubMed ID: 2116808.
    Abstract:
    Intravenous infusion of gamma-glutamyl-L-dopa (25 micrograms/kg/min) for 10 h in normal humans caused a natriuresis of 46.5 mmol of sodium without an increase in plasma renin activity and was associated with small but significant falls in blood pressure. In a second study the oral bioavailability of gludopa was estimated in normal subjects and found to be low (less than 2%). The increase in urine dopamine excretion and the natriuretic effect of gludopa were much larger after intravenous infusion than oral dosing.
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