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  • Title: New furin inhibitors based on weakly basic amidinohydrazones.
    Author: Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T.
    Journal: Bioorg Med Chem Lett; 2011 Jan 15; 21(2):836-40. PubMed ID: 21168329.
    Abstract:
    A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K(i) values of 0.46 and 0.59μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups.
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