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  • Title: Evaluation of cardiac iron load by cardiac magnetic resonance in thalassemia.
    Author: Merchant R, Joshi A, Ahmed J, Krishnan P, Jankharia B.
    Journal: Indian Pediatr; 2011 Sep; 48(9):697-701. PubMed ID: 21169646.
    Abstract:
    OBJECTIVE: To quantify myocardial iron stores by Cardiac Magnetic Resonance (CMR). DESIGN: Prospective cohort study. SETTING: Thalassemia center in a teaching hospital. PARTICIPANTS: 60 transfusion dependant thalassemia major patients and 10 controls during 2008-2009. METHODS: MRI T2* for cardiac iron load and cardiac functions was performed on a 1.5 Tesla Siemens Sonata machine using the thalassemia tools software. Ejection fraction (EF) was measured using standard CMR sequence and EF <56% considered as cardiac dysfunction. Quantification of iron deposition was categorized as T2* <10 milliseconds (ms) as high risk, 10-20 ms as intermediate risk and >20 ms as low risk. Simultaneous liver iron T2* values were categorized into normal i.e. >6.3 ms, mild iron overload 6.3-2.7 ms , moderate iron overload 2.7- 1.4 ms and severe iron overload <1.4 ms. Pretransfusion serum ferritin levels were simultaneously determined. Data was analyzed by paired and unpaired t test of mean. RESULTS: Of 60 patients, 50% had no cardiac siderosis; 33.3% had mild to moderate and while 16.7% had severe cardiac siderosis . In contrast, only 8.3% had normal liver iron values, 55.7% had mild to moderate and 36% had severe iron stores. The mean serum ferritin of all 60 cases was 3528.6 ± 1958.6 ng/mL. There was a statistically significant difference in the mean cardiac T2* of patients (23.45 ± 13.4 ms) as compared to controls (32.67 ± 2.68 ms) (P<0.01). CONCLUSIONS: Thalassemia patients had significantly higher cardiac iron stores as compared to controls. Serum ferritin and liver iron values did not correlate with cardiac iron values. Three of 10 patients <10 years showed evidence of myocardial siderosis.
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