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  • Title: Early pregnancy blood lead and spontaneous abortion.
    Author: Vigeh M, Yokoyama K, Kitamura F, Afshinrokh M, Beygi A, Niroomanesh S.
    Journal: Women Health; 2010 Dec; 50(8):756-66. PubMed ID: 21170817.
    Abstract:
    Although evidence tends to suggest that high levels of lead exposure increase the risk of spontaneous abortion, we do not yet know whether moderate- to low-level exposure elevates risk. Among 351 women (aged 16 to 35 years, with single pregnancies) who were registered for a longitudinal study, 15 (4.3%) women experienced spontaneous abortion after the 12th week of gestation and before the 20th week. We collected participants' blood samples during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Mean ± standard deviation of blood lead was 3.8 ± 2.0 μg/dl (range 1.0-20.5 μg/dl) with a geometric mean of 3.5 μg/dl. Mean blood lead concentrations did not differ significantly between spontaneous abortion cases and ongoing pregnancies (3.51 ± 1.42 and 3.83 ± 1.99 μg/dl, respectively). The findings suggest that in apparently healthy women, low blood lead levels (mean < 5 μg/dl) measured in early pregnancy may not be a risk factor for spontaneous abortion.
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