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  • Title: [Standard doses of tadalafil for different ED patients].
    Author: Chen Y, Xu ZP, Zhu WD, Sun C, Dai YT.
    Journal: Zhonghua Nan Ke Xue; 2010 Sep; 16(9):860-3. PubMed ID: 21171275.
    Abstract:
    OBJECTIVE: To observe the effects of different doses of tadalafil on ED, and to search for appropriate doses for the treatment of different ED patients. METHODS: Based on the baseline peak systolic velocity (PSV) of cavernosal arteries, 136 ED patients were divided into Groups A (PSV > 15 cm/s), B (PSV > 15 cm/s), C (PSV < 15 cm/s) and D (PSV <15 cm/s) to receive oral tadalafil at 10 mg (Groups A and C) and 5 mg (Groups B and D) on alternate days for 4 weeks. All of them were scored on IIEF-5 and detected for PSVs of the bilateral cavernosal arteries by color Doppler ultrasonography and intracavernous injection of prostaglandin E1 before and after the medication. RESULTS: After 4 weeks of tadalafil treatment, IIEF-5 scores and PSVs were remarkably improved in all the four groups as compared with the baseline (P < 0.01), significantly higher in Group C than in D (P < 0.01), but with no significant differences between A and B. CONCLUSION: Oral tadalafil can improve PSV and hence penile erection in ED patients either at a low or a high dose. To reduce side effects and drug cost, the patients with PSV >15 cm/s can be medicated at 5 mg, while those with PSV < 15 cm/s at 10 mg or more on alternate days.
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