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  • Title: [The effect of Astragalus membranaceus (Fisch) bge. on lipid peroxidation and NO level of myocardium from rats with diabetic nephropathy].
    Author: Chen GR, Liu Y, Mao SZ, Li JM, Zhen CF.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2001 May; 17(2):186-8. PubMed ID: 21171416.
    Abstract:
    AIM: To study the effect of astragalus membranaceus (Fisch) bge. on the lipid peroxidation and NO level of myocardium from rats with diabetic nephropathy. METHODS: Male wistar rats were divided into five groups: (1) A normal control group, (2) Diabetes group, (3) Diabetic nephropathy group, (4) Diabetic nephropathy group complicated with acute renal function damage, (5) Astragalus membranaceus (Fisch) bge. treatment group. The activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), nitric oxide synthase (NOS) and content of malondialdehyde (MDA), nitric oxide (NO) was determined biochemically from myocardial homogenate among different groups. RESULTS: The activity of GSH-Px, SOD decreased and the content of MDA, NO and NOS activity increased in each experimental group compared with control group, as was more obvious in diabetic nephropathy group with acute renal function damage, which astragalus membranaceus (Fisch) bge could improve. CONCLUSION: Astragalus membranaceus (Fisch) bge. could protect the myocardium in diabetic nephropathy by inhibiting lipid peroxidation and decreasing the level of NO.
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