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  • Title: The synapsins and the regulation of synaptic function.
    Author: Bähler M, Benfenati F, Valtorta F, Greengard P.
    Journal: Bioessays; 1990 Jun; 12(6):259-63. PubMed ID: 2117454.
    Abstract:
    Synapsin I and II are a family of synaptic vesicle-associated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.
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