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  • Title: Total synthesis of lamellarins D, H, and R and ningalin B.
    Author: Li Q, Jiang J, Fan A, Cui Y, Jia Y.
    Journal: Org Lett; 2011 Jan 21; 13(2):312-5. PubMed ID: 21175172.
    Abstract:
    A concise total synthesis of lamellarins D (7 steps), H (7 steps), and R (5 steps) and ningalin B (5 steps) is achieved starting from the corresponding aldehydes and amines. The synthesis features three oxidative reactions as key steps in a biomimetic manner, involving an AgOAc-mediated oxidative coupling reaction to construct the pyrrole core, a Pb(OAc)(4)-induced oxidative cyclization to form the lactone, and Kita's oxidation reaction to form the pyrrole-arene C-C bond.
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