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  • Title: Synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines.
    Author: Arumugam N, Periyasami G, Raghunathan R, Kamalraj S, Muthumary J.
    Journal: Eur J Med Chem; 2011 Feb; 46(2):600-7. PubMed ID: 21177001.
    Abstract:
    A facile and one-pot synthesis of a series of novel spiropyrrolidines/pyrrolizidines with β-lactam substituent has been accomplished through 1,3-dipolar cycloaddition reaction of alkenyl esters derived from β-lactam aldehyde as dipolarophile with the dipole azomethine ylide derived from 1,2- and 1,3-diketones and secondary amino acids. The synthesized compounds were evaluated for antimicrobial activities and found to exhibit relatively good antibacterial activity at lower concentration against four human bacterial pathogens.
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