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  • Title: [Neural stem cells transplantation improved learning and memory abilities in Alzheimer's disease rat].
    Author: Yang C, Zhang Q, Wang SC, Qiao P, Zhang Z.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2007 May; 23(2):159-61. PubMed ID: 21179758.
    Abstract:
    AIM: To investigate whether transplantation of neural stem cells can ameliorate learning and memory abilities in Alzheimer's disease (AD) rats. METHODS: Neural stem cells were isolated from dentate gyrus of hippocampus of newborn rats. After labeled with Hoechst33258, neural stem cells were grafted into the hippocampus of AD rats. 2 or 4 weeks post transplantation, the rats underwent behavioral testing using Y-maze trial. Fluorescence observation and immunohistochemistry were used after the rats were sacrificed. RESULTS: Neural stem cells grafted into hippocampus of AD rats could not only survive well, but also possessed the capacity of continuous proliferation and migrate along the hippocampus. CONCLUSION: Neural stem cells grafted into hippocampus of AD rats can not only survive well, possess the capacity of continuous proliferation, but also ameliorate memory defects in Alzheimer's disease rats.
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