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  • Title: Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review.
    Author: Mohammed MI, Desmulliez MP.
    Journal: Lab Chip; 2011 Feb 21; 11(4):569-95. PubMed ID: 21180774.
    Abstract:
    This review examines the current state of the art lab-on-a-chip and microfluidic based biosensor technologies used in the detection of cardiac biomarkers. The determination and quantification of blood based, cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions, where time delay has a major impact on short and longer-term outcomes of a patient. The design and manufacturing of biomarker detection systems are multi-disciplinary in nature and require researchers to have knowledge of both life sciences and engineering for the full potential of this field to be realised. This review will therefore provide a comprehensive overview of chip based immunosensing technology as applied to cardiac biomarker detection, while discussing the potential suitability and limitations of each configuration for incorporation within a clinical diagnostics device suitable for point-of-care applications.
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