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  • Title: The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.
    Author: Imbriglio JE, DiRocco D, Bodner R, Raghavan S, Chen W, Marley D, Esser C, Holt TG, Wolff MS, Taggart AK, Waters MG, Tata JR, Colletti SL.
    Journal: Bioorg Med Chem Lett; 2011 May 01; 21(9):2721-4. PubMed ID: 21185185.
    Abstract:
    Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties.
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