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  • Title: Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI.
    Author: Babu B, Liu Y, Plaunt A, Riddering C, Ogilvie R, Westrate L, Davis R, Ferguson A, Mackay H, Rice T, Chavda S, Wilson D, Lin S, Kiakos K, Hartley JA, Lee M.
    Journal: Biochem Biophys Res Commun; 2011 Jan 21; 404(3):848-52. PubMed ID: 21185262.
    Abstract:
    An orthogonally positioned diamino/dicationic polyamide f-IPI 2 was synthesized. It has enhanced binding affinity, and it showed comparable sequence specificity to its monoamino/monocationic counterpart f-IPI 1. Results from CD and DNase I footprinting studies confirmed the minor groove binding and selectivity of polyamides 1 and 2 for the cognate sequence 5'-ACGCGT-3'. SPR studies provided their binding constants: 2.4 × 10(8)M(-1) for diamino 2, which is ∼4 times higher than 5.4 × 10(7)M(-1) for its monoamino analogue 1.
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