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  • Title: Amphioxus Tbx6/16 and Tbx20 embryonic expression patterns reveal ancestral functions in chordates.
    Author: Belgacem MR, Escande ML, Escriva H, Bertrand S.
    Journal: Gene Expr Patterns; 2011; 11(3-4):239-43. PubMed ID: 21185952.
    Abstract:
    T-box transcription factors are found in all metazoans and play diverse roles during embryogenesis. In the cephalochordate amphioxus, nine T-box genes were previously identified. In this work we undertook the analysis of the embryonic expression pattern of Tbx6/16 and Tbx20, the last two T-box genes for which no such data are available. We found that Tbx6/16 is expressed in the unsegmented paraxial mesoderm, in a subpopulation of neurons, and in the tail epidermis. Comparison with the expression patterns of the different vertebrate orthologues indicates a conserved role of those genes in posterior mesoderm formation in chordates. Tbx20 expression is detected in the ventral mesoderm of amphioxus embryos, in cells that are proposed to be precursors of the amphioxus myocardium, in some neurons of the neural tube, and in the pre-oral pit which is thought to be the homologue of the vertebrate adenohypophysis. In vertebrates, Tbx20 is also one of the first genes expressed in the embryonic heart field, suggesting that the function of this gene in heart development has been conserved during chordate evolution.
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