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  • Title: In vitro activities of seven quinolone derivatives against Neisseria gonorrhoeae.
    Author: van der Willigen AH, Degener JE, Vogel M, Stolz E, Wagenvoort JH.
    Journal: Arzneimittelforschung; 1990 Jun; 40(6):684-5. PubMed ID: 2118763.
    Abstract:
    The in vitro activities of ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 10 penicillinase-producing N. gonorrhoeae strains (PPNG's), 10 non-PPNG's, 10 non-penicillinase-producing penicillin-resistant chromosomally mediated N. gonorrhoeae strains (CMRNG's) 3 N. gonorrhoeae strains with a decreased sensitivity against quinolones compounds and one tetracycline-resistant penicillinase-producing N. gonorrhoeae (TRNG/PPNG), strain were evaluated in this study. The non PPNG, PPNG, CMRNG and TRNG/PPNG strains showed good to excellent sensitivity to the quinolones tested. The N. gonorrhoeae strains with a decreased sensitivity against quinolones showed higher MIC (minimum inhibitory concentration) values.
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