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  • Title: In vivo morphological damage induced by a new benzimidazole prodrug in Echinococcus multilocularis metacestodes.
    Author: Walchshofer N, Delabre-Defayolle I, Paris J, Petavy AF.
    Journal: J Pharm Sci; 1990 Jul; 79(7):606-8. PubMed ID: 2118956.
    Abstract:
    Benzimidazoles are the most widely used compounds in chemotherapy of alveolar hydatid disease (AHD), but long-term administration is required to reach detectable plasma levels. N-Methoxycarbonyl N'-2-nitro 4-trifluoromethyl phenyl thiourea (2) was prepared as a potential prodrug of (5-trifluoromethyl-1H-benzimidazole-2-yl)-carbamic acid methyl ester. Biological effects of 2 were evaluated in gerbils (Meriones unguiculatus) against the causative agent of AHD, Echinococcus multilocularis metacestodes, through a transmission electron microscopy study. Significant morphological damage of tegument and protoscolices occurred after an 18-day treatment. The treatment of AHD by using the prodrug form of the benzimidazole deserves further study.
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