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  • Title: Bovine serum albumin-directed synthesis of biocompatible CdSe quantum dots and bacteria labeling.
    Author: Wang Q, Ye F, Fang T, Niu W, Liu P, Min X, Li X.
    Journal: J Colloid Interface Sci; 2011 Mar 01; 355(1):9-14. PubMed ID: 21190695.
    Abstract:
    A simple method was developed for preparing CdSe quantum dots (QDs) using a common protein (bovine serum albumin (BSA)) to sequester QD precursors (Cd(2+)) in situ. Fluorescence (FL) and absorption spectra showed that the chelating time between BSA and Cd(2+), the molar ratio of BSA/Cd(2+), temperature, and pH are the crucial factors for the quality of QDs. The average QD particle size was estimated to be about 5 nm, determined by high-resolution transmission electron microscopy. With FL spectra, Fourier transform infrared spectra, and thermogravimetric analysis, an interesting mechanism was discussed for the formation of the BSA-CdSe QDs. The results indicate that there might be conjugated bonds between CdSe QDs and -OH, -NH, and -SH groups in BSA. In addition, fluorescence imaging suggests that the QDs we designed can successfully label Escherichia coli cells, which gives us a great opportunity to develop biocompatible tools to label bacteria cells.
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