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  • Title: [Fetal RHD genotyping by PCR using plasma from D negative pregnant women].
    Author: Achargui S, Tijane M, Benchemsi N.
    Journal: Transfus Clin Biol; 2011 Feb; 18(1):13-9. PubMed ID: 21190884.
    Abstract:
    AIM OF THE STUDY: Free fetal DNA in maternal blood offers a non invasive method for prenatal diagnosis. The aim of this study is to perform fetal RHD genotyping by conventional PCR in D negative pregnant women of Moroccan origin. PATIENTS AND METHODS: Plasma sample from 120 D negative pregnant women from 10 to 40 gestational weeks were tested by conventional PCR for the presence of exons 7 and 10 of RHD gene. The results were compared with the RhD phenotype of the newborns. RESULTS: In this study, the positive and the negative predictive value of the fetal RhD status were 98.7 and 96.7%, respectively. CONCLUSION: These results demonstrate de feasibility of fetal RHD genotyping by conventional PCR in D negative pregnant women of Moroccan origin.
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