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  • Title: Spectrophotometric and spectrofluorimetric methods for determination of Racecadotril.
    Author: Ali NW, Elghobashy MR, Mahmoud MG, Mohammed MA.
    Journal: Pak J Pharm Sci; 2011 Jan; 24(1):19-23. PubMed ID: 21190913.
    Abstract:
    Two accurate and sensitive spectrophotometric and spectrofluorimetric methods were developed for determination of Racecadotril. In the first method reduction of Fe3+ into Fe2+ in presence of o-phenanthroline by Racecadotril to form a stable orange-red ferroin chelate [Fe-(Phen)3]2+ was the basis for its determination. The absorbance at 510 nm was measured and linear correlation was obtained in the concentration range of 2.5-25 µg mL(-1). In the second method the native fluorescence of Racecadotril in acetonitrile solvent at λ=319 nm when excitation was at 252 nm is used for its determination. Linear correlation was obtained in the concentration range of 50 to 500 ng mL(-1). The proposed methods were applied for determination of Racecadotril in bulk powder with mean accuracy of 100.39±1.239 for the spectrophotometric method and 100.09±1.042 for the spectrofluorimetric method. The proposed methods were successfully applied for determination of Racecadotril in its pharmaceutical dosage form.
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