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  • Title: [Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats].
    Author: Li SQ, Li WB, Sun XC, Li QJ, Chen XL, Ai J.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2004 Aug; 20(3):296-9. PubMed ID: 21192429.
    Abstract:
    AIM: To observe the changes of cyclooxygenase-2 (COX-2) expression and especially the time course of the changes in dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats. METHODS: COX-2 immunohistochemistry staining was used in rat formalin pain model. RESULTS: Compared with control group the number and immunostaining density of COX-2 immunoreactive cells in the laminae I-VI of the dorsal horn of the spinal cord increased significantly 4 h, 1 d and 3 d after formalin injection (P < 0.05). The most obvious increase was observed 1 d after the injection. CONCLUSION: COX-2 in the dorsal horn of the spinal cord is involved in the formalin-induced inflammatory pain and hyperalgesia.
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