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  • Title: [Effect of bombesin on IFN-induced fever and AVP content in brain of rats].
    Author: Zhou XY, Zhao SF.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2004 Aug; 20(3):300-3. PubMed ID: 21192430.
    Abstract:
    AIM: To determine whether bombesin prevents IFN-alpha-induced fever and it's possible mechanism. METHODS: Effects of BN on changes in body temperature and arginine vasopressin(AVP) content in the ventral septal area(VSA) and hypothalamus were measured in the rats following intracerebroventricular (ICV) injection of IFN-alpha. RESULTS: (1) IFN-alpha produced a dose-dependent rise in colonic temperature simultaneously with increase in AVP content in the VSA in the rats. (2) BN produced a dose-dependent hypothermia and significantly elevated AVP content in the VSA in rats. (3) BN injected intracerebroventricularly at 30 min after IFN-alpha prevented the increase in colonic temperature which recovered to the control level as well as AVP content in the VSA in rats at 150 min. CONCLUSION: AVP in the VSA may play a role in IFN-alpha-induced fever. AVP in the VSA may play a partial role in the BN antipyretic action and hypothermic action.
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