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  • Title: Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate.
    Author: Park S, Bando T, Shinohara K, Nishijima S, Sugiyama H.
    Journal: Bioconjug Chem; 2011 Feb 16; 22(2):120-4. PubMed ID: 21192678.
    Abstract:
    We designed and synthesized a Py-Im polyamide seco-CBI conjugate protected by a photocleavable group and demonstrated that it was selectively activated by UV irradiation both in vitro and in vivo. Sequence-specific alkylating Py-Im polyamides containing photolabile linkers may be useful for developing novel chemical- or enzyme-activated anticancer agents and may facilitate spatiotemporal control of gene expression.
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