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  • Title: Modelling the way Ku binds DNA.
    Author: Hu S, Cucinotta FA.
    Journal: Radiat Prot Dosimetry; 2011 Feb; 143(2-4):196-201. PubMed ID: 21196465.
    Abstract:
    Ku plays a crucial role in the non-homologous end joining pathway to repair DNA double-strand breaks. In this study, we modelled the full-length Ku heterodimer from the truncated crystal structure and NMR structure, and conducted a series of docking and molecular dynamics simulations in an effort to probe the structural, dynamical and energetic features of each domain in free Ku and Ku-DNA complexes.
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