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  • Title: Aging and calcium metabolism.
    Author: Fujita T.
    Journal: Adv Second Messenger Phosphoprotein Res; 1990; 24():542-7. PubMed ID: 2119658.
    Abstract:
    It is imperative to understand calcium metabolism under a unified concept, despite the vast concentration difference among the three major calcium compartments in human body. Total body calcium homeostasis supported by adequate calcium intake and normal skeletal metabolism is quite important to maintain adequate extra- and intracellular calcium concentration gradient and consequent signal transduction system mediated by calcium entry into the cell. Aging and diseases are associated with blunting of the calcium concentration gradient, due to calcium deficiency and consequent secondary hyperparathyroidism.
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