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  • Title: Signal-to-noise analysis of biomedical photoacoustic measurements in time and frequency domains.
    Author: Telenkov S, Mandelis A.
    Journal: Rev Sci Instrum; 2010 Dec; 81(12):124901. PubMed ID: 21198041.
    Abstract:
    Sensitivity analysis of photoacoustic measurements is conducted using estimates of the signal-to-noise ratio (SNR) achieved under two different modes of optical excitation. The standard pulsed time-domain photoacoustic imaging is compared to the frequency-domain counterpart with a modulated optical source. The feasibility of high-SNR continuous wave depth-resolved photoacoustics with frequency-swept (chirp) modulation pattern has been demonstrated. Utilization of chirped modulation waveforms achieves dramatic SNR increase of the periodic signals and preserves axial resolution comparable to the time-domain method. Estimates of the signal-to-noise ratio were obtained using typical parameters of piezoelectric transducers and optical properties of tissue.
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