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  • Title: Influence of the 5-HT3 receptor antagonist ondansetron on gastric sensorimotor function and nutrient tolerance in healthy volunteers.
    Author: Janssen P, Vos R, Van Oudenhove L, Tack J.
    Journal: Neurogastroenterol Motil; 2011 May; 23(5):444-9, e175. PubMed ID: 21199175.
    Abstract:
    BACKGROUND: Serotonin is believed to be involved in the regulation of the gastric accommodation reflex in man however which receptor subtype(s) are involved remains to be elucidated. METHODS: Eleven healthy subjects (nine men, age 19-30) underwent a gastric barostat and a drinking test after treatment with either placebo or ondansetron (8 mg intravenously). During the barostat protocol an intragastric flaccid bag was stepwise distended (2 mmHg increments 2 min) to determine gastric compliance and sensitivity to distention. Subsequently, the pressure level was set at intra-abdominal pressure +2 mmHg while volume was followed before and after administration of a liquid meal (200 mL; 300 kcal). During the drink test volunteers drank at a rate of 15 mL min(-1) until maximal satiation. Results (mean ± SEM) were compared using t-tests and mixed model analysis. KEY RESULTS: Gastric compliance was not significantly altered by ondansetron (51.5 ± 5.6 vs 49.2 ± 5.2 mL mmHg(-1)), neither were the pressure thresholds for first perception or discomfort. Ondansetron treatment did not affect basal gastric tone (173 ± 14 vs 156 ± 12 mL), neither did it affect the amplitude of the meal-induced relaxation (160 ± 52 vs 131 ± 43 mL) or the maximum volume increase after the meal (264 ± 54 mL vs 234 ± 51 mL). During the drinking test the amount of liquid meal ingested at maximum satiation was significantly increased by ondansetron (784 ± 74 vs 907 ± 64 mL, P < 0.05). CONCLUSIONS & INFERENCES: These data suggest that 5-HT acting at 5-HT(3) receptors is not involved in the control of gastric sensorimotor function, but contributes to the regulation of hunger and satiation in man.
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