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  • Title: [Effect of hypoxia on activity of hypothalamo-pituitary- adrenal-cortex axis in rat].
    Author: Wu Y, Du JZ.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2001 Nov; 17(4):317-9. PubMed ID: 21207683.
    Abstract:
    AIM AND METHODS: In this experiment we used the methods of simulated hypoxia in a low-pressure cabin and RIA to investigate the effect of hypoxia on secretion of corticotropin-releasing factor (CRF) from hypothalamus and corticosterone from adrenal-cortex. And compare the effects of hypoxia on secretion of CRF and corticosterone in rat exposed to hypoxia for different time. RESULTS: During acute hypoxia the secretion of CRF and level of plasma corticosterone rose significantly comparing with control. After 5 days of exposed to hypoxia the augment of secretion of CRF and level of plasma corticosterone decreased and to 15 days exposed to hypoxia the secretion of CRF and level of plasma corticosterone approached to control. CONCLUSION: Hypoxia (2 h, 24 h) significantly activated HPA axis. After 5 days exposed to hypoxia the activity of HPA axis attenuated and began to recovery. After 15 days exposed to chronic hypoxia the activity of HPA axis has recovered to control level.
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