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  • Title: [The changes of coagulation and fibrinolysis function on hypoxia adaptation mechanism].
    Author: Cui JH, Zhang XZ, Xie YZ, Zhou XM, Ha ZD.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2001 Nov; 17(4):363-5. PubMed ID: 21207702.
    Abstract:
    AIM AND METHODS: To determine their Antithrombin-III (AT-III), Plasminogen (PLG), D-Dimer (DD), tissue-Plasminogen Activator (t-PA), Plasminogen Activator Inhibitor (PAI), Fibrinogen (Fg) and alpha2-Plasmin, inhibitor (alpha2-PI), when 40 subjects entered to high altitude, and compared with healthy flatlander. RESULTS: At high altitude (3 700 m, 5 380 m) the AT-III abd t-PA were lower significantly than that of the flatlander (1 400m) (P < 0.05 or P < 0.01). The higher altitude subjects enter, the lower count will take (P < 0.01), and with the longer stay time, there was a higher count (P < 0.05 or P < 0.01). The 7th day at high altitude, PLG. DD. PAI. alpha2-PI and Fg were much higher than the flatlander's (P < 0.05 or P < 0.01), and with the higher elevation, there were higher datas, and with the longer stay time, there were lower datas (P < 0.05 or P < 0.01). Compare the a half of year at 3 700m with the flatlands, the results isn't discrepant (P > 0.05). CONCLUSION: There is a coagulation-function disorder at high altitude, the results shows that coagulation and fibrinolysis are activated and fibrinolysis is inhibited yet, so the coagulation-fibrinolysis balance is destroyed. This effects lead to a hypercoagulation and hypo fibrinolysis state.
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