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Title: Sobetirome: a selective thyromimetic for the treatment of dyslipidemia. Author: Tancevski I, Demetz E, Eller P. Journal: Recent Pat Cardiovasc Drug Discov; 2011 Jan; 6(1):16-9. PubMed ID: 21208155. Abstract: Atherosclerosis and its clinical sequelae still represent the primary cause of death in Western societies. During the past 25 years, a novel drug class to treat dyslipidemia, a main risk factor for coronary artery disease, emerged: liver- and thyroid hormone receptor isoform β-selective analogs. The present review will discuss the recent patents applied for sobetirome (GC-1), which set the course for the establishment of a novel approach to lower plasma cholesterol and triglycerides. We will focus on the major mechanisms conferring sobetirome lipid-lowering properties, including the induction of hepatic LDL receptor, the promotion of the so-called reverse cholesterol transport, and finally the induction of bile acid production and biliary sterol secretion. In summary, thyromimetics such as sobetirome may represent a useful treatment for combined hyperlipidemia, which is associated with a major cardiovascular risk.[Abstract] [Full Text] [Related] [New Search]