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  • Title: Combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids.
    Author: Wang XS, Sheng J, Lu L, Yang K, Li YL.
    Journal: ACS Comb Sci; 2011 Mar 14; 13(2):196-9. PubMed ID: 21210708.
    Abstract:
    A combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives is described by a reaction of 2-aminobenzohydrazides with two equivalents of aldehydes or ketones in ionic liquids catalyzed by iodine. Controlling the reaction temperature or reducing the activity of the substrates, respectively, the intermediate products of hydrazones were obtained first, and then they were applied to react with various aromatic aldehydes without being separated, resulting in structural diversification of quinazolinone derivatives.
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