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  • Title: [Study on serum differentially expressed proteins in discordance of congenital esotropic phenotypes in monozygotic twins].
    Author: Liu GX, Yan ZY, Li H.
    Journal: Zhonghua Yan Ke Za Zhi; 2010 Nov; 46(11):964-8. PubMed ID: 21211289.
    Abstract:
    OBJECTIVE: To investigate the serum differentially expressed proteins in discordance of congenital esotropia phenotypes in monozygotic twins and non-strabismus ones. METHODS: SELDI-TOF-MS technology was used to detect the changes of protein expression in a couple of twins with phenotype discordance esotropia (twins A is orthotropia and twins B is esotropia). In addition, two non-twins esotropia and 2 orthotropia children with the same age were chosen. The obtained serum differential expression proteome was validated in 12 non-twins esotropia and 18 orthotropia children and initial predication by proteinum database. RESULTS: The result of SELDI-TOF-MS in 6 serums showed that four differential expression protein peaks, the molecular weight of these different proteins were 4146, 4801, 7786 and 5859, and the former 3 proteins were down-regulated and last one was up-regulated. Their features were fairly coincident with glucagons precursor, pituitary adenylate cyclase activating peptide (PACAP), cAMP dependent protein kinase inhibitor α and anti-metastasis gene (antigen). CONCLUSIONS: The expression of different proteins among the esotropic and orthotopic children was existed. The expression of different proteins was main down-regulated in the strabismus patients. Glucagons precursor, protein kinase A inhibitor α and PACAP may be related with occurrence of congenital esotropia.
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