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  • Title: PEG based hyperbranched polymeric hollow nanospheres.
    Author: Cao H, Dong Y, O'Rorke S, Wang W, Pandit A.
    Journal: Nanotechnology; 2011 Feb 11; 22(6):065604. PubMed ID: 21212483.
    Abstract:
    The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.
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