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  • Title: Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells.
    Author: Namekata I, Tsuruoka N, Tsuneoka Y, Matsuda T, Takahara A, Tanaka Y, Suzuki T, Takahashi T, Iida-Tanaka N, Tanaka H.
    Journal: Biol Pharm Bull; 2011; 34(1):153-5. PubMed ID: 21212535.
    Abstract:
    We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (I(Ks)). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC(50) value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 µM and 4.9 µM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.
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