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  • Title: DPPH-scavenging activities and structure-activity relationships of phenolic compounds.
    Author: Zheng CD, Li G, Li HQ, Xu XJ, Gao JM, Zhang AL.
    Journal: Nat Prod Commun; 2010 Nov; 5(11):1759-65. PubMed ID: 21213975.
    Abstract:
    Thirty-eight phenolic compounds (including 31 flavonoids) were examined for their DPPH radical-scavenging activities, and structure-activity relationships were evaluated. Specifically, the presence of an ortho-dihydroxyl structure in phenolics is largely responsible for their excellent anti-radical activity. 3-Hydroxyl was also essential to generate a high radical-scavenging activity. An increasing number of hydroxyls on flavones with a 3',4'-dihydroxyl basic structure, the presence of a third hydroxyl group at C-5', a phloroglucinol structure, glycosylation and methylation of the hydroxyls, and some other hydroxyls, for example 5-, and 7-hydroxyl in ring A, decreased the radical-scavenging activities of flavonoids and other phenolics.
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