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  • Title: Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.
    Author: Lee S, Kim JN, Lee HK, Yoon KS, Shin KD, Kwon BM, Han DC.
    Journal: Bioorg Med Chem Lett; 2011 Feb 01; 21(3):977-9. PubMed ID: 21215627.
    Abstract:
    A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.
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