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  • Title: Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
    Author: Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR.
    Journal: J Clin Endocrinol Metab; 1990 Dec; 71(6):1416-20. PubMed ID: 2121775.
    Abstract:
    Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.
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