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  • Title: [Newly developed stenocardia: effect of diet with increased amount of polyunsaturated fatty acids of the omega-3 group on blood lipids and apolipoproteins].
    Author: Kalinkina OM, Gratsianskiĭ NA, Perova NV, Metel'skaia VA, Zykova VP, Olfer'ev AM, Oganov RG.
    Journal: Kardiologiia; 1990 Jul; 30(7):34-8. PubMed ID: 2122053.
    Abstract:
    The effects of omega-3 polyunsaturated fatty acids (PUSF), a 4-week fish diet--350 g of scomber a day, on the blood lipid-apolipoprotein spectrum were evaluated in 22 patients with primary angina pectoris as compared to 8 control subjects received hospital protein-, fat-, carbohydrate-, and calorie-balanced diet No. 10 differing in omega-3 PUSF content (5 and 0.03 g/day, respectively). The fish diet caused a significant reduction in total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) in patients with hypercholesterolemia, however, the normal cholesterol (under 200 mg/dl) and LDLC (under 130 mg/dl) levels were reached only in a small proportion of the patients. There was a hypotriglyceridemic effect of omega-3 PUSF that was more pronounced at initially high triglyceride concentrations. Heterogeneous changes were found in LDLC levels with the fish diet. i.e. from a great decrease at initially high LDLC levels to a small increase at initially low LDLC in patients with hypertriglyceridemia and low levels of high density lipoproteins. It was concluded that a fish diet should be included into a complex of measures aimed at the secondary prevention of coronary heart disease in patients with primary angina concurrent with hypercholesterolemia (even moderate) and hypertriglyceridemia unassociated with hypoalphacholesterolemia.
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