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  • Title: miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.
    Author: Chen Q, Chen X, Zhang M, Fan Q, Luo S, Cao X.
    Journal: Dig Dis Sci; 2011 Jul; 56(7):2009-16. PubMed ID: 21221794.
    Abstract:
    INTRODUCTION: MicroRNAs (miRNAs) are a class of small (19-25 nucleotides) noncoding RNAs that regulate the expressions of a wide variety of genes, including some involved in cancer development. Some recent studies show that DNA methylation contributes to down-regulation of microRNA-137 (miR-137) during tumorigenesis. Whether down-regulation of miR-137 also exists in gastric cancer is unknown. AIM: Our aim was to test the hypothesis that down-regulation of miR-137 also exists in gastric cancer. METHODS: Expression of levels of miR-137 were examined using real-time PCR on paired gastric cancer and adjacent non-cancerous tissues. The methylation status is detected by MSP. RESULTS: Results show that miR-137 is downregulated by hypermethylation of the promoter in gastric cancer tissues. Epigenetic silencing of miR-137 induced an up-regulation of its targets, Cdc42. Restoration of the miR-137 expression in gastric cancer cell lines downregulated the Cdc42 expression. Restoration of the miR-137 and inactivation of Cdc42 induce apoptosis and cell cycle G1 arrest in gastric cancer cells. Furthermore, the miR-137 expression was found to be inversely correlated with CDC42 expression in gastric caner. CONCLUSIONS: miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.
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