These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biophysical and molecular mechanisms of Shaker potassium channel inactivation.
    Author: Hoshi T, Zagotta WN, Aldrich RW.
    Journal: Science; 1990 Oct 26; 250(4980):533-8. PubMed ID: 2122519.
    Abstract:
    The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.
    [Abstract] [Full Text] [Related] [New Search]