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  • Title: Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase.
    Author: Beretz A, Anton R, Stoclet JC.
    Journal: Experientia; 1978 Aug 15; 34(8):1054-5. PubMed ID: 212288.
    Abstract:
    The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of which have a potency equivalent to that of papaverine. Some structure activity relationships are drawn.
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