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  • Title: The relative contributions of processing speed and cognitive load to working memory accuracy in multiple sclerosis.
    Author: Leavitt VM, Lengenfelder J, Moore NB, Chiaravalloti ND, DeLuca J.
    Journal: J Clin Exp Neuropsychol; 2011 Jun; 33(5):580-6. PubMed ID: 21229437.
    Abstract:
    Cognitive symptoms of multiple sclerosis (MS) include processing-speed deficits and working memory impairment. The precise manner in which these deficits interact in individuals with MS remains to be explicated. We hypothesized that providing more time on a complex working memory task would result in performance benefits for individuals with MS relative to healthy controls. Fifty-three individuals with clinically definite MS and 36 matched healthy controls performed a computerized task that systematically manipulated cognitive load. The interval between stimuli presentations was manipulated to provide increasing processing time. The results confirmed that individuals with MS who have processing-speed deficits significantly improve in performance accuracy when given additional time to process the information in working memory. Implications of these findings for developing appropriate cognitive rehabilitation interventions are discussed.
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